Abstract: Resource allocation is an important dimension to explore how manufacturing spatial network affects regional development. Taking the Yangtze River economic belt as the research area, gravity model and social network analysis method were used to explore the high-dimensional framework of manufacturing spatial network resource allocation, and then spatial econometric model was used to analyze the spillover effect of it, so as to reveal the internal logic of the development of manufacturing spatial network scope. Research finds that high dimensional structure is not only the overall abstraction of spatial network resource allocation but also an effective tool to quantitatively explore its logic and effect. The high-dimensional structure of manufacturing spatial network resource allocation shows a structural evolution from fewer centers to more centers, and the connection is becoming closer and closer. The direction of inter-regional interaction has changed from “internal double & external single” to “internal double & external double”. The agglomeration, diffusion and deployment of node cities support the effective operation of high-dimensional structure. The three forces jointly guide the spatial allocation of resources and enable the development process of the region. The resource allocation of manufacturing spatial network will have a significant positive local effect and spillover effect on the development of manufacturing agglomeration, and both effects have obvious regional heterogeneity.